Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0042385
Title: A quantitative model of human jejunal smooth muscle cell electrophysiology
Authors: Poh, Y.C.
Corrias, A. 
Cheng, N.
Buist, M.L. 
Issue Date: 17-Aug-2012
Source: Poh, Y.C., Corrias, A., Cheng, N., Buist, M.L. (2012-08-17). A quantitative model of human jejunal smooth muscle cell electrophysiology. PLoS ONE 7 (8) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0042385
Abstract: Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated. © 2012 Poh et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/54753
ISSN: 19326203
DOI: 10.1371/journal.pone.0042385
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