Please use this identifier to cite or link to this item: https://doi.org/10.1038/nmat2915
Title: A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability
Authors: Li, P.
Poon, Y.F.
Li, W.
Zhu, H.-Y.
Yeap, S.H.
Cao, Y.
Qi, X.
Zhou, C.
Lamrani, M.
Beuerman, R.W.
Kang, E.-T. 
Mu, Y.
Li, C.M.
Chang, M.W.
Jan Leong, S.S.
Chan-Park, M.B.
Issue Date: Feb-2011
Source: Li, P., Poon, Y.F., Li, W., Zhu, H.-Y., Yeap, S.H., Cao, Y., Qi, X., Zhou, C., Lamrani, M., Beuerman, R.W., Kang, E.-T., Mu, Y., Li, C.M., Chang, M.W., Jan Leong, S.S., Chan-Park, M.B. (2011-02). A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability. Nature Materials 10 (2) : 149-156. ScholarBank@NUS Repository. https://doi.org/10.1038/nmat2915
Abstract: Despite advanced sterilization and aseptic techniques, infections associated with medical implants have not been eradicated. Most present coatings cannot simultaneously fulfil the requirements of antibacterial and antifungal activity as well as biocompatibility and reusability. Here, we report an antimicrobial hydrogel based on dimethyldecylammonium chitosan (with high quaternization)-graft-poly(ethylene glycol) methacrylate (DMDC-Q-g-EM) and poly(ethylene glycol) diacrylate, which has excellent antimicrobial efficacy against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Fusarium solani. The proposed mechanism of the antimicrobial activity of the polycationic hydrogel is by attraction of sections of anionic microbial membrane into the internal nanopores of the hydrogel, like an ĝ€̃ anion spongeĝ€™, leading to microbial membrane disruption and then microbe death. We have also demonstrated a thin uniform adherent coating of the hydrogel by simple ultraviolet immobilization. An animal study shows that DMDC-Q-g-EM hydrogel coating is biocompatible with rabbit conjunctiva and has no toxicity to the epithelial cells or the underlying stroma. © 2011 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/54720
ISSN: 14761122
DOI: 10.1038/nmat2915
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