Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.icheatmasstransfer.2008.06.003
Title: A numerical analysis of effects of vortex breakdown on oxygen transport in a micro-bioreactor
Authors: Yu, P. 
Lee, T.S. 
Zeng, Y. 
Low, H.T. 
Keywords: Micro-bioreactor
Oxygen transport
Vortex breakdown
Issue Date: Nov-2008
Source: Yu, P., Lee, T.S., Zeng, Y., Low, H.T. (2008-11). A numerical analysis of effects of vortex breakdown on oxygen transport in a micro-bioreactor. International Communications in Heat and Mass Transfer 35 (9) : 1141-1146. ScholarBank@NUS Repository. https://doi.org/10.1016/j.icheatmasstransfer.2008.06.003
Abstract: Vortex breakdown effects on oxygen concentration distributions in a micro-bioreactor were investigated by a finite volume model. The bioreactor consists of a cylindrical chamber with a rotating bottom wall. The minimum oxygen concentration and volumetric oxygen transfer coefficient were summarized at different Reynolds numbers, Damkohler numbers as well as bioreactor aspect ratios. It was found that vortex breakdown extends the axis region where oxygen concentration is higher. Also vortex breakdown tends to induce a uniform oxygen concentration distribution in the bioreactor. Thus, the occurrence of vortex breakdown is of benefit to animal cell culture. Compared with that in the bioreactor with a rigid lid, vortex breakdown in the bioreactor with free surface may be better for animal cell culture as the bubble has larger size and may occur apart from the axis. © 2008 Elsevier Ltd. All rights reserved.
Source Title: International Communications in Heat and Mass Transfer
URI: http://scholarbank.nus.edu.sg/handle/10635/54658
ISSN: 07351933
DOI: 10.1016/j.icheatmasstransfer.2008.06.003
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