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|Title:||A molecular brush approach to enhance quantum yield and suppress nonspecific interactions of conjugated polyelectrolyte for targeted far-red/near-infrared fluorescence cell imaging|
|Authors:||Pu, K.-Y. |
|Source:||Pu, K.-Y., Li, K., Liu, B. (2010-09-09). A molecular brush approach to enhance quantum yield and suppress nonspecific interactions of conjugated polyelectrolyte for targeted far-red/near-infrared fluorescence cell imaging. Advanced Functional Materials 20 (17) : 2770-2777. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201000495|
|Abstract:||A red-fluorescent conjugated polyelectrolyte (CPE, P2) is grafted with dense poly(ethylene glycol) (PEG) chains via click chemistry and subsequently modified with folic acid to form a molecular brush based cellular probe (P4). P4 self-assembles into a core-shell nanostructure in aqueous medium with an average size of 130 nm measured by laser light scattering. As compared to P2, P4 possesses not only a substantially higher quantum yield (11%), but also reduced nonspecific interactions with biomolecules in aqueous medium due to the shielding effect of PEG. In conjunction with its high photostability and low cytotoxicity, utilization of P4 as a far-red/near-infrared cellular probe allows for effective visualization and discrimination of MCF-7 cancer cells from NIH-3T3 normal cells in a high contrast, selective, and nonviral manner. This study thus demonstrates a flexible molecular brush approach to overcome the intrinsic drawbacks of CPEs for advanced bioimaging applications. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Advanced Functional Materials|
|Appears in Collections:||Staff Publications|
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