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Title: A model of slow wave propagation and entrainment along the stomach
Authors: Buist, M.L. 
Corrias, A. 
Poh, Y.C.
Keywords: Carbon monoxide
Interstitial cell of Cajal
Resting membrane potential
Smooth muscle cell
Issue Date: Sep-2010
Citation: Buist, M.L., Corrias, A., Poh, Y.C. (2010-09). A model of slow wave propagation and entrainment along the stomach. Annals of Biomedical Engineering 38 (9) : 3022-3030. ScholarBank@NUS Repository.
Abstract: Interstitial cells of Cajal (ICC) isolated from different regions of the stomach generate spontaneous electrical slow wave activity at different frequencies, with cells from the proximal stomach pacing faster than their distal counterparts. However, in vivo there exists a uniform pacing frequency; slow waves propagate aborally from the proximal stomach and subsequently entrain distal tissues. Significant resting membrane potential (RMP) gradients also exist within the stomach whereby membrane polarization generally increases from the fundus to the antrum. Both of these factors play a major role in the macroscopic electrical behavior of the stomach and as such, any tissue or organ level model of gastric electrophysiology should ensure that these phenomena are properly described. This study details a dual-cable model of gastric electrical activity that incorporates biophysically detailed single-cell models of the two predominant cell types, the ICC and smooth muscle cells. Mechanisms for the entrainment of the intrinsic pacing frequency gradient and for the establishment of the RMP gradient are presented. The resulting construct is able to reproduce experimentally recorded slow wave activity and provides a platform on which our understanding of gastric electrical activity can advance. © 2010 Biomedical Engineering Society.
Source Title: Annals of Biomedical Engineering
ISSN: 00906964
DOI: 10.1007/s10439-010-0051-1
Appears in Collections:Staff Publications

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