Please use this identifier to cite or link to this item: https://doi.org/10.1002/mabi.201200481
Title: A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation
Authors: Yu, T.
Chua, C.K.
Tay, C.Y.
Wen, F.
Yu, H.
Chan, J.K.Y.
Chong, M.S.K.
Leong, D.T. 
Tan, L.P.
Keywords: Adhesion
Biomaterials
HMSCs
Micropattern
Myogenesis
Issue Date: Jun-2013
Source: Yu, T.,Chua, C.K.,Tay, C.Y.,Wen, F.,Yu, H.,Chan, J.K.Y.,Chong, M.S.K.,Leong, D.T.,Tan, L.P. (2013-06). A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation. Macromolecular Bioscience 13 (6) : 799-807. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201200481
Abstract: Human mesenchymal stem cells (MSCs) derived from various origins show varied differentiation capability. Recent work shows that cell shape manipulation via micropatterning can modulate the differentiation of bone-marrow-derived MSCs. Herein, the effect of micropatterning on the myogenesis of MSCs isolated from three different sources (bone marrow, fetal tissue, and adipose) is reported. All the well-aligned cells, regardless of source, predominantly commit to myogenic lineage, as shown by the significant upregulation of myogenic gene markers and positive myosin heavy chain staining. It is demonstrated that our novel micropattern can be used as a generic platform for inducing myogenesis of MSCs from different sources and may also have the potential to be extended to induce other lineage commitment. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Bioscience
URI: http://scholarbank.nus.edu.sg/handle/10635/54208
ISSN: 16165187
DOI: 10.1002/mabi.201200481
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