Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biosystems.2003.07.002
Title: A computational model of a class of gene networks with positive and negative controls
Authors: Chen, P.C.Y. 
Keywords: Automata
Formal languages
Gene networks
Pathways
Positive and negative controls
Issue Date: Jan-2004
Source: Chen, P.C.Y. (2004-01). A computational model of a class of gene networks with positive and negative controls. BioSystems 73 (1) : 13-24. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biosystems.2003.07.002
Abstract: This article proposes a computational framework for modelling the logical behavior of a class of gene networks. We characterize the basic behavior of genes in terms of a state-and-transition structure, and model the individual genes as language-generating automata. We consider positive and negative controls as the interaction mechanisms among the genes, and treat such controls as constraints (also expressed in automata) imposed on the behavior of the gene network. By computing the intersection of the languages generated by the gene models and the constraints, we obtain the complete set of pathways in a gene network. Implications and possible improvement of this work are discussed. © 2003 Elsevier Ireland Ltd. All rights reserved.
Source Title: BioSystems
URI: http://scholarbank.nus.edu.sg/handle/10635/54008
ISSN: 03032647
DOI: 10.1016/j.biosystems.2003.07.002
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