Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53713
Title: Fast and Accurate mapping of Next Generation Sequencing Data
Authors: CHANDANA TIKIRI BANDARA TENNAKOON
Keywords: next,generation,sequencing,BWT,mismatch,indel
Issue Date: 19-Aug-2013
Source: CHANDANA TIKIRI BANDARA TENNAKOON (2013-08-19). Fast and Accurate mapping of Next Generation Sequencing Data. ScholarBank@NUS Repository.
Abstract: Next Generation Sequencing (NGS) has opened up new possibilities in genomic studies. However, studying the vast amounts of data produced by these technologies present several challenges. In many applications, millions of reads will to be mapped to very large genomes of size around 3 GB. Furthermore, the mapping needs to take into account errors in the form of mismatches and indels. Burrows-Wheeler transform (BWT) is a data structure used prominently by sequence aligners. In this thesis I introduce BWT based algorithms to efficiently and accurately align NGS data.
URI: http://scholarbank.nus.edu.sg/handle/10635/53713
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
TennakoonCTB.pdf1.72 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

75
checked on Dec 11, 2017

Download(s)

126
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.