Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53704
Title: Evaluation of Thymoquinone for cytotoxic activity against human Breast cancer cell lines and tumor xenograft in nude mice
Authors: WOO CHERN CHIUH
Keywords: thymoquinone, breast cancer, natural product, apoptosis, ROS, p38
Issue Date: 19-Aug-2013
Source: WOO CHERN CHIUH (2013-08-19). Evaluation of Thymoquinone for cytotoxic activity against human Breast cancer cell lines and tumor xenograft in nude mice. ScholarBank@NUS Repository.
Abstract: Thymoquinone (TQ) is a natural compound isolated from Nigella sativa. The activity of TQ on breast carcinoma were investigated both in vitro and in vivo. TQ was found to inhibit the growth of breast cancer cells as well as combined with known chemotherapeutic drugs for enhanced cytotoxicity. TQ was found to induce apoptosis and inhibit the migration and invasion of breast cancer cells. Moreover, TQ was found to induce PPAR-gamma activity, whereby this induction might responsible for TQ-induced suppression of survivin. In addition, increased ROS production and p38 phosphorylation play a crucial role in TQ-induced growth inhibition and apoptosis. TQ was found to suppress breast tumor growth in nude mice and combined with doxorubicin to produce greater suppression. TQ increased the hepatic level of anti-oxidant enzymes/molecules in these mice. Together, this study demonstrates the potential anticancer activities of TQ in human breast carcinoma possibly via ROS, PPAR-gamma and p38 pathways.
URI: http://scholarbank.nus.edu.sg/handle/10635/53704
Appears in Collections:Ph.D Theses (Open)

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