Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53689
Title: A Cullin-1 Based SCF E3 Ligase Complex Directs Two Distinct Modes of Neuronal Pruning in Drosophila Melanogaster
Authors: WONG JING LIN JACK
Keywords: Cullin-1, Dendrite Pruning, Drosophiila, Insulin signaling, Axon pruning, E3 ligase
Issue Date: 10-Jan-2014
Source: WONG JING LIN JACK (2014-01-10). A Cullin-1 Based SCF E3 Ligase Complex Directs Two Distinct Modes of Neuronal Pruning in Drosophila Melanogaster. ScholarBank@NUS Repository.
Abstract: The mechanism governing the remodeling of the nervous system is hugely unknown. Drosophila melanogaster, provides us with an highly manipulative platform to gain in-depth understanding of the remodeling of the nervous system. During metamorphosis, Class IV ddaC neurons undergo a process known as dendrite pruning. In this study, an RNAi screen was carried out and a Cullin-1 based SCF E3 ligase complex was identified to be essential for ddaC dendrite pruning. Furthermore, the Cullin-1 based SCF E3 ligase is also required for pruning of MB ? neurons in the CNS. This study also revealed that while EcR-B1 and Sox14 act upstream of the E3 ligase complex to regulate its abundance, Mical acts in parallel to the complex to mediate ddaC dendrite pruning. Furthermore, we demonstrated that InR/PI3K/TOR pathway is attenuated by Cullin-1 based SCF E3 ligase complex during dendrite pruning, likely though ubiquitination and degradation of key positive regulator, Akt.
URI: http://scholarbank.nus.edu.sg/handle/10635/53689
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
WongJingLinJackPhD Thesis May 2014.pdf7.89 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

162
checked on Dec 11, 2017

Download(s)

187
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.