Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cardiores.2003.12.022
Title: Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro
Authors: Heng, B.C. 
Haider, H.Kh. 
Sim, E.K.-W.
Cao, T. 
Ng, S.C.
Keywords: Cardiomyocytes
Differentiation
Myocardial infarction
Stem cells
Transplantation
Issue Date: 1-Apr-2004
Source: Heng, B.C., Haider, H.Kh., Sim, E.K.-W., Cao, T., Ng, S.C. (2004-04-01). Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro. Cardiovascular Research 62 (1) : 34-42. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cardiores.2003.12.022
Abstract: Most studies on stem cell transplantation therapy on myocardially infarcted animal models and phase-I human clinical trials have focused on the use of undifferentiated stem cells. There is a strong possibility that some degree of cardiomyogenic differentiation of stem cells in vitro prior to transplantation would result in higher engraftment efficiency, as well as enhanced myocardial regeneration and recovery of heart function. Additionally, this may also alleviate the probability of spontaneous differentiation of stem cells into undesired lineages and reduces the risk of teratoma formation, in the case of embryonic stem cells. The development of efficient protocols for directing the cardiomyogenic differentiation of stem cells in vitro will also provide a useful model for molecular studies and genetic manipulation. This review therefore critically examines the various techniques that could possibly be used to direct and control the cardiomyogenic differentiation of stem cells in vitro. © 2004 European Society of Cardiology. Elsevier B.V. All rights reserved.
Source Title: Cardiovascular Research
URI: http://scholarbank.nus.edu.sg/handle/10635/53552
ISSN: 00086363
DOI: 10.1016/j.cardiores.2003.12.022
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

130
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

128
checked on Nov 16, 2017

Page view(s)

69
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.