Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10495-009-0315-0
Title: NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy
Authors: Shen, H.-M. 
Tergaonkar, V.
Keywords: Cancer
IKK
Inhibitors
Kinase
NFκB
P65
Signaling
Issue Date: Apr-2009
Source: Shen, H.-M., Tergaonkar, V. (2009-04). NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy. Apoptosis 14 (4) : 348-363. ScholarBank@NUS Repository. https://doi.org/10.1007/s10495-009-0315-0
Abstract: It has become increasingly clear that deregulation of the NFκB signaling cascade is a common underlying feature of many human ailments including cancers. The past two decades of intensive research on NFκB has identified the basic mechanisms that govern the functioning of this pathway but uncovering the details of why this pathway works differently in different cellular contexts or how it interacts with other signaling pathways remains a challenge. A thorough understanding of these processes is needed to design better and more efficient therapeutic approaches to treat complex diseases like cancer. In this review, we summarize the literature documenting the involvement of NFκB in cancer, and then focus on the approaches that are being undertaken to develop NFκB inhibitors towards treatment of human cancers. © 2009 Springer Science+Business Media, LLC.
Source Title: Apoptosis
URI: http://scholarbank.nus.edu.sg/handle/10635/53543
ISSN: 13608185
DOI: 10.1007/s10495-009-0315-0
Appears in Collections:Staff Publications

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