Please use this identifier to cite or link to this item: https://doi.org/10.1083/jcb.200708159
Title: Drosophila neuroblast asymmetric divisions: Cell cycle regulators, asymmetric protein localization, and tumorigenesis
Authors: Chia, W. 
Somers, W.G.
Wang, H. 
Issue Date: 28-Jan-2008
Citation: Chia, W., Somers, W.G., Wang, H. (2008-01-28). Drosophila neuroblast asymmetric divisions: Cell cycle regulators, asymmetric protein localization, and tumorigenesis. Journal of Cell Biology 180 (2) : 267-272. ScholarBank@NUS Repository. https://doi.org/10.1083/jcb.200708159
Abstract: Over the past decade, many of the key components of the genetic machinery that regulate the asymmetric division of Drosophila melanogaster neural progenitors, neuroblasts, have been identified and their functions elucidated. Studies over the past two years have shown that many of these identified components act to regulate the self-renewal versus differentiation decision and appear to function as tumor suppressors during larval nervous system development. In this paper, we highlight the growing number of molecules that are normally considered to be key regulators of cell cycle events/progression that have recently been shown to impinge on the neuroblast asymmetric division machinery to control asymmetric protein localization and/or the decision to self-renew or differentiate. © The Rockefeller University Press.
Source Title: Journal of Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/53530
ISSN: 00219525
DOI: 10.1083/jcb.200708159
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