Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.ophtha.2012.07.063
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dc.title | Retinal vascular geometry and glaucoma: The Singapore Malay Eye Study | |
dc.contributor.author | Wu, R. | |
dc.contributor.author | Cheung, C.Y.-L. | |
dc.contributor.author | Saw, S.M. | |
dc.contributor.author | Mitchell, P. | |
dc.contributor.author | Aung, T. | |
dc.contributor.author | Wong, T.Y. | |
dc.date.accessioned | 2014-05-20T02:30:18Z | |
dc.date.available | 2014-05-20T02:30:18Z | |
dc.date.issued | 2013-01 | |
dc.identifier.citation | Wu, R., Cheung, C.Y.-L., Saw, S.M., Mitchell, P., Aung, T., Wong, T.Y. (2013-01). Retinal vascular geometry and glaucoma: The Singapore Malay Eye Study. Ophthalmology 120 (1) : 77-83. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ophtha.2012.07.063 | |
dc.identifier.issn | 01616420 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/53490 | |
dc.description.abstract | Purpose: To determine the associations of geometric measurements (tortuosity, branching angle, and fractal dimension) of retinal vessels with glaucoma. Design: Population-based, cross-sectional study. Participants: Persons aged 40 to 80 years who participated in the Singapore Malay Eye Study (n = 3280; 78.7% response rate). Methods: Quantitative retinal vascular parameters (tortuosity, branching angle, and fractal dimension) were measured from digital retinal fundus photographs using a computer-assisted program following a standardized grading protocol. Glaucoma was diagnosed according to the International Society of Geographic and Epidemiological Ophthalmology classification system. Main Outcome Measures: The associations among retinal vascular parameters with glaucoma, the main glaucoma subtype primary open-angle glaucoma (POAG), and ocular hypertension (OHT). Results: A total of 123 persons (4.4% of the 2789 participants) had glaucoma in the final analysis, 87 (70.7%) of whom were diagnosed with POAG. After adjusting for age, sex, body mass index, diabetes, hypertension, smoking, axial length, and intraocular pressure (IOP), decreased retinal arteriolar tortuosity (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.38-2.18, comparing lowest vs. highest quartiles), decreased retinal venular tortuosity (OR, 1.59; 95% CI, 1.29-1.97), and narrower retinal venular branching angle (OR, 1.22; 95% CI, 1.00-1.48) were associated with glaucoma. Similar associations were found between these retinal vascular parameters and POAG. Decreased retinal vascular fractal dimension was associated with OHT (OR 1.37; 95% CI, 1.04-1.82). Conclusions: Certain features of retinal vascular geometry are associated with glaucomatous optic neuropathy independently of vascular risk factors and IOP. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2013 American Academy of Ophthalmology. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ophtha.2012.07.063 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1016/j.ophtha.2012.07.063 | |
dc.description.sourcetitle | Ophthalmology | |
dc.description.volume | 120 | |
dc.description.issue | 1 | |
dc.description.page | 77-83 | |
dc.description.coden | OPHTD | |
dc.identifier.isiut | 000313011700013 | |
Appears in Collections: | Staff Publications |
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