Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.12-10414
Title: Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography
Authors: Koh, V.T.
Tham, Y.-C.
Cheung, C.Y. 
Wong, W.-L.
Baskaran, M.
Saw, S.-M. 
Wong, T.Y. 
Aung, T.
Issue Date: Aug-2012
Source: Koh, V.T., Tham, Y.-C., Cheung, C.Y., Wong, W.-L., Baskaran, M., Saw, S.-M., Wong, T.Y., Aung, T. (2012-08). Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Investigative Ophthalmology and Visual Science 53 (9) : 5853-5859. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.12-10414
Abstract: Purpose. To determine the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (±SD) age of study subjects was 52.84 ± 6.14 years, 50.1% were male, and all subjects had normal visual fields with no signs of glaucoma or glaucoma suspect. The mean overall, minimum, superior, and inferior GC-IPL thicknesses were 82.78 ± 7.01 μm, 79.67 ± 9.17 μm, 83.30 ± 7.89 μm, and 80.16 ± 8.31 μm, respectively. In multiple linear regression analysis, GC-IPL thickness was significantly associated with age (β = -0.202, P < 0.001), female sex (β = -2.367, P < 0.001), axial length (β = -1.279, P = 0.002), and mean peripapillary retinal nerve fiber layer (RNFL) thickness (β = 0.337, P < 0.001). IOP, central corneal thickness, disc area, serum glucose level, and history of diabetes mellitus had no significant influence on GC-IPL thickness. Conclusions. Thinner GC-IPL was independently associated with older age, female sex, longer axial length, and thinner RNFL thickness. These factors should be taken into account when interpreting GC-IPL thickness measurements with HD-OCT for glaucoma assessment. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
Source Title: Investigative Ophthalmology and Visual Science
URI: http://scholarbank.nus.edu.sg/handle/10635/53414
ISSN: 01460404
DOI: 10.1167/iovs.12-10414
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

47
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

44
checked on Nov 16, 2017

Page view(s)

38
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.