Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53401
Title: Cholinergic augmentation modulates visual task performance in sleep-deprived young adults
Authors: Chuah, L.Y.M. 
Chee, M.W.L. 
Keywords: Attention
Cholinergic system
fMRI
Parietal cortex
Sleep deprivation
Visual cortex
Visual short-term memory
Issue Date: 29-Oct-2008
Citation: Chuah, L.Y.M., Chee, M.W.L. (2008-10-29). Cholinergic augmentation modulates visual task performance in sleep-deprived young adults. Journal of Neuroscience 28 (44) : 11369-11377. ScholarBank@NUS Repository.
Abstract: Using 24 h of total sleep deprivation to perturb normal cognitive function, we conducted a double-blind, placebo-controlled crossover study to evaluate the effect of the acetylcholinesterase inhibitor, donepezil, on behavioral performance and task-related brain activation in 28 healthy, young, adult volunteers. The behavioral tasks involved the parametric manipulation of visual short-term memory load and perceptual load in separate experiments indirectly evaluating attention. Sleep deprivation significantly reduced posterior cortical activation (intraparietal sulcus and extrastriate cortex) at all levels of visual memory as well as perceptual load. Donepezil modulated an individual's performance in both tasks in accordance to whether accuracy declined after sleep deprivation without treatment. Critically, there were significant correlations between donepezil-induced increases in neural activation in the posterior cortical areas and improvement in accuracy. Reduced visual short-term memory after sleep deprivation may thus originate from a decline in visual attention and/or visual processing. Cholinergic augmentation can alleviate these deficits in individuals vulnerable to the effects of sleep deprivation, but it may have neutral or negative effects on those resistant to sleep deprivation. Copyright © 2008 Society for Neuroscience.
Source Title: Journal of Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/53401
ISSN: 02706474
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

62
checked on Feb 27, 2018

WEB OF SCIENCETM
Citations

55
checked on Apr 23, 2018

Page view(s)

60
checked on Jun 1, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.