Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53392
Title: Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
Authors: Yu, F. 
Morin, X.
Cai, Y. 
Yang, X. 
Chia, W. 
Issue Date: 18-Feb-2000
Source: Yu, F.,Morin, X.,Cai, Y.,Yang, X.,Chia, W. (2000-02-18). Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell 100 (4) : 399-409. ScholarBank@NUS Repository.
Abstract: Asymmetric localization is a prerequisite for inscuteable (insc) to function in coordinating and mediating asymmetric cell divisions in Drosophila. We show here that Partner of Inscuteable (Pins), a new component of asymmetric divisions, is required for Inscuteable to asymmetrically localize. In the absence of pins, Inscuteable becomes cytoplasmic and asymmetric divisions of neuroblasts and mitotic domain 9 cells show defects reminiscent of insc mutants. Pins colocalizes with Insc and interacts with the region necessary and sufficient for directing its asymmetric localization. Analyses of pins function in neuroblasts reveal two distinct steps for Insc apical cortical localization: A pins-independent, bazooka-dependent initiation step during delamination (interphase) and a later maintenance step during which Baz, Pins, and Insc localization are interdependent.
Source Title: Cell
URI: http://scholarbank.nus.edu.sg/handle/10635/53392
ISSN: 00928674
Appears in Collections:Staff Publications

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