Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53379
Title: MECHANISMS GOVERNING EPITHELIAL MESENCHYMAL TRANSITION IN BLADDER CARCINOMA
Authors: SIM WEN JING
Keywords: epithelial mesenchymal transition, bladder cancer, TGFb, HGF, MAPK, invasion
Issue Date: 23-Dec-2013
Source: SIM WEN JING (2013-12-23). MECHANISMS GOVERNING EPITHELIAL MESENCHYMAL TRANSITION IN BLADDER CARCINOMA. ScholarBank@NUS Repository.
Abstract: Epithelial mesenchymal transition (EMT) is a developmental process governing major steps in morphogenesis and organogenesis. EMT can be induced by a variety of growth factors. EMT is characterized by the loss of apico-basal polarity of epithelial cells and the acquisition of a fibroblastic-like morphology favourable for migration. Some mechanisms governing developmental EMT have been co-opted by carcinoma cells during the early phase of invasion. In this study, we focus on a bladder carcinoma cell-line model system to unravel the mechanisms driving invasive migration. We analyzed expression profiling and identified pathways activated at different times during the execution of the EMT program stimulated by hepatocyte growth factor (HGF). We utilized small molecular weight kinase inhibitors to interfere with c-MET downstream signaling systems and identified drugs that block EMT and invasion in matrigel. The potential of the drugs to prevent bladder carcinoma invasion was validated in an orthotopic bladder mouse model.
URI: http://scholarbank.nus.edu.sg/handle/10635/53379
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