Please use this identifier to cite or link to this item:
|Title:||The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets|
|Citation:||Cui, J., Gong, Z., Shen, H.-M. (2013-08). The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets. Biochimica et Biophysica Acta - Reviews on Cancer 1836 (1) : 15-26. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbcan.2013.02.003|
|Abstract:||Autophagy is an evolutionarily conserved pathway for degradation of cytoplasmic proteins and organelles via lysosome. Proteins coded by the autophagy-related genes ( Atgs) are the core molecular machinery in control of autophagy. Among the various biological functions of autophagy identified so far, the link between autophagy and cancer is probably among the most extensively studied and is often viewed as controversial. Autophagy might exert a dual role in cancer development: autophagy can serve as an anti-tumor mechanism, as defective autophagy (e.g., heterozygous knockdown Beclin 1 and Atg7 in mice) promotes the malignant transformation and spontaneous tumors. On the other hand, autophagy functions as a protective or survival mechanism in cancer cells against cellular stress (e.g., nutrient deprivation, hypoxia and DNA damage) and hence promotes tumorigenesis and causes resistance to therapeutic agents. Liver cancer is one of the common cancers with well-established etiological factors including hepatitis virus infection and environmental carcinogens such as aflatoxin and alcohol exposure. In recent years, the involvement of autophagy in liver cancer has been increasingly studied. Here, we aim to provide a systematic review on the close cross-talks between autophagy and liver cancer, and summarize the current status in development of novel liver cancer therapeutic approaches by targeting autophagy. It is believed that understanding the molecular mechanisms underlying the autophagy modulation and liver cancer development may provoke the translational studies that ultimately lead to new therapeutic strategies for liver cancer. © 2013 Elsevier B.V.|
|Source Title:||Biochimica et Biophysica Acta - Reviews on Cancer|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 18, 2018
WEB OF SCIENCETM
checked on Jul 9, 2018
checked on Jun 22, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.