Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ydbio.2010.08.004
Title: Developing in vivo biophysics by fishing for single molecules
Authors: Wang, X.
Wohland, T. 
Korzh, V. 
Keywords: C. elegans
FCS
FRET
Medaka
SMT
TIRF
Zebrafish
Issue Date: 1-Nov-2010
Source: Wang, X., Wohland, T., Korzh, V. (2010-11-01). Developing in vivo biophysics by fishing for single molecules. Developmental Biology 347 (1) : 1-8. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ydbio.2010.08.004
Abstract: Single-molecule techniques (SMT) provide the possibility to quantitatively analyze the action of single molecules. SMTs can resolve the distribution of states of an ensemble of molecules, collecting information that is otherwise not accessible by typical ensemble techniques. Until now, the application of SMTs in developmental biology was limited. Several recent studies illustrate the possibility to investigate the behavior of single biological molecules in invertebrates such as Caenorhabditis elegans and transparent embryos of model teleosts. These studies have paved the way for the application of fluorescence-based SMTs, e.g. fluorescence correlation spectroscopy, fluorescent energy transfer, or single particle tracking, in developmental biology. This review aims to define SMTs applicable in developmental biology, and discuss properties of an ideal animal model. © 2010 Elsevier Inc.
Source Title: Developmental Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/53342
ISSN: 00121606
DOI: 10.1016/j.ydbio.2010.08.004
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