Please use this identifier to cite or link to this item: https://doi.org/10.1109/ICBBE.2010.5516560
Title: A metabonomic investigation of zebrafish exposed to bisphenol A
Authors: Duan, Z.-H.
Zhu, L.
Zhao, N.
Bu, W.-J.
Lam, S.-H. 
Gong, Z.-Y. 
Ong, C.-N. 
Keywords: Bisphenol A
GC-MS
Metabonomics
Toxicity
Zebrafish
Issue Date: 2010
Source: Duan, Z.-H.,Zhu, L.,Zhao, N.,Bu, W.-J.,Lam, S.-H.,Gong, Z.-Y.,Ong, C.-N. (2010). A metabonomic investigation of zebrafish exposed to bisphenol A. 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010 : -. ScholarBank@NUS Repository. https://doi.org/10.1109/ICBBE.2010.5516560
Abstract: Metabonomics approach based on the GC-MS technique was used to characterize the perturbation of volatile and semi-volatile components in zebrafish embryos induced by bisphenol A (BPA) for 8 d since fertilization. The exposure concentrations of BPA were 0, 0.5, 1.5 and 4.5 mg/L, around assumed a "safe level" (1.5 mg/L) that stated by US EPA. Results indicated that, the relative proportions of 9,12-Octadecadienoic acid and myo-sitosterol were decreased dramatically at 1.5 mg/L BPA, and those of saturated fatty acid (SAF), amino acid and D-myo-inositol were increased significantly. Therefore, 1.5 mg/L BPA would disturb the regular metabolizing of zebrafish. These alterations were related with the physiological and histological changes found in the exposure stage. The integration of metabonomics approach and conventional toxicology study may provide invaluable information in assessing the risk of environment pollutants.
Source Title: 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
URI: http://scholarbank.nus.edu.sg/handle/10635/53266
ISBN: 9781424447138
DOI: 10.1109/ICBBE.2010.5516560
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