Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.talanta.2010.08.031
Title: Preparation and application of rifamycin-capped (3-(2-O-β- cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography
Authors: Zhao, J.
Tan, D.
Chelvi, S.K.T.
Yong, E.L.
Lee, H.K. 
Gong, Y. 
Keywords: β-Cyclodextrin
Chiral separation
Chiral stationary phase
High-performance liquid chromatography
Rifamycin
Issue Date: 15-Nov-2010
Source: Zhao, J., Tan, D., Chelvi, S.K.T., Yong, E.L., Lee, H.K., Gong, Y. (2010-11-15). Preparation and application of rifamycin-capped (3-(2-O-β- cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography. Talanta 83 (1) : 286-290. ScholarBank@NUS Repository. https://doi.org/10.1016/j.talanta.2010.08.031
Abstract: Rifamycin-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)- propylsilyl-appended silica particles (RCD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by the treatment of bromoacetate-substituted-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) -propylsilyl-appended silica particles (BACD-HPS) with rifamycin SV in anhydrous acetonitrile. The stationary phase is characterized by means of elemental analysis and Fourier-transform infrared spectroscopy. This new CSP has a chiral selector with two recognition sites: rifamycin and β-cyclodextrin (β-CD). The chromatographic behavior of RCD-HPS was studied with several disubstituted benzenes and some chiral drug compounds under reversed-phase HPLC mobile phase conditions. The results show that RCD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of rifamycin and β-CD. © 2010 Elsevier B.V.
Source Title: Talanta
URI: http://scholarbank.nus.edu.sg/handle/10635/53103
ISSN: 00399140
DOI: 10.1016/j.talanta.2010.08.031
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