Please use this identifier to cite or link to this item: https://doi.org/10.1002/cncr.24485
Title: Pathway sensitivity analysis for detecting pro-proliferation activities of oncogenes and tumor suppressors of epidermal growth factor receptor- extracellular signal-regulated protein kinase pathway at altered protein levels
Authors: Li, H. 
Choong, Y.U.
Xiao, H.M.
Xiang, H.L.
Bao, W.L. 
Boon, C.L. 
Yu, Z.C.
Keywords: Biologic networks
Epidermal growth factor receptor-extracellular signal-regulated protein kinase pathway
Oncogene
Pathway simulation
System biology
Issue Date: 15-Sep-2009
Source: Li, H., Choong, Y.U., Xiao, H.M., Xiang, H.L., Bao, W.L., Boon, C.L., Yu, Z.C. (2009-09-15). Pathway sensitivity analysis for detecting pro-proliferation activities of oncogenes and tumor suppressors of epidermal growth factor receptor- extracellular signal-regulated protein kinase pathway at altered protein levels. Cancer 115 (18) : 4246-4263. ScholarBank@NUS Repository. https://doi.org/10.1002/cncr.24485
Abstract: BACKGROUND: Mathematic models and sensitivity analyses of biologic pathways have been used for exploring the dynamics and for detecting the key components of signaling pathways. METHODS: The authors previously developed a mathematic model of the epidermal growth factor receptor-extracellular signal-regulated protein kinase (EGFR-ERK) pathway using ordinary differential equations from existing EGFR-ERK pathway models. By using prolonged ERK activation as an indicator that may lead to cell proliferation under certain circumstances, in the current study, a pathway sensitivity analysis was performed to test its capability of detecting pro-proliferative activities through altered protein levels to examine the effects on ERK activation. RESULTS: The analysis revealed that 12 of 20 oncoproteins and 4 of 5 tumor suppressors were detected, consistent with reported experimental works. Because pathway dynamics depend on many factors, some of which were not included in the current models, failure to detect all known oncogenes and tumor suppressors can be because of the failure to include relevant crosstalk to other pathway components. CONCLUSIONS: Overall, the current results indicated that pathway sensitivity analysis is a useful approach for detecting and distinguishing pro-proliferation activities of oncoproteins and suppressed proliferative activities of tumor suppressors at altered protein levels at least in the EGFR-ERK model. © 2009 American Cancer Society.
Source Title: Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/53083
ISSN: 0008543X
DOI: 10.1002/cncr.24485
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

5
checked on Dec 13, 2017

WEB OF SCIENCETM
Citations

6
checked on Nov 15, 2017

Page view(s)

38
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.