Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53076
Title: Orthogonal array design as a chemometric method for the optimization of analytical procedures part 3.* five-level design and its application in a polarographic reaction system for selenium determination
Authors: Lan, W.G.
Wong, M.K. 
Chee, K.K.
Sin, Y.M. 
Keywords: Chemometric optimization
Differential-pulse polarography
Five-level orthogonal array design
Response surface methodology
Selenium determination
Issue Date: 1995
Source: Lan, W.G.,Wong, M.K.,Chee, K.K.,Sin, Y.M. (1995). Orthogonal array design as a chemometric method for the optimization of analytical procedures part 3.* five-level design and its application in a polarographic reaction system for selenium determination. The Analyst 120 (2) : 273-279. ScholarBank@NUS Repository.
Abstract: The theory and methodology of a five-level orthogonal array design for the optimization of analytical procedures were developed. In the theoretical section, the construction and characteristics of the OA25(56) matrix are described in detail while orthogonality is proved by means of a fourth-order polynomial model. Next, the assignment of experiments in the OA25(56) matrix is illustrated, followed by the data analysis strategy, in which significant/non-significant influence for each factor is quantitatively evaluated by the analysis of variance (ANOVA) technique including the percentage contribution, and the differences among five levels for each factor that has a significant influence are determined by Duncan's multiple F-test. Finally, the response surface methodology for the OA25(56) matrix is developed by using the equations obtained from the proof on orthogonality. In the application section, the reaction system for selenium determination by differential-pulse polarography, as a practical example, is employed to demonstrate the application of the OA25(56) matrix in the area of analytical chemistry.
Source Title: The Analyst
URI: http://scholarbank.nus.edu.sg/handle/10635/53076
ISSN: 00032654
Appears in Collections:Staff Publications

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