Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11427-010-0079-3
Title: Medaka fish stem cells and their applications
Authors: Yi, M.S. 
Hong, N.
Li, Z.D.
Yan, Y. 
Wang, D.K.
Zhao, H.B. 
Hong, Y.H. 
Keywords: Chimera
Medaka
Nuclear transplant
Pluripotency
Semi-cloning
Stem cells
Issue Date: 2010
Source: Yi, M.S.,Hong, N.,Li, Z.D.,Yan, Y.,Wang, D.K.,Zhao, H.B.,Hong, Y.H. (2010). Medaka fish stem cells and their applications. Science China Life Sciences 53 (4) : 426-434. ScholarBank@NUS Repository. https://doi.org/10.1007/s11427-010-0079-3
Abstract: Stem cells are present in developing embryos and adult tissues of multicellular organisms. Owing to their unique features, stem cells provide excellent opportunities for experimental analyses of basic developmental processes such as pluripotency control and cell fate decision and for regenerative medicine by stem cell-based therapy. Stem cell cultures have been best studied in 3 vertebrate organisms. These are the mouse, human and a small laboratory fish called medaka. Specifically, medaka has given rise to the first embryonic stem (ES) cells besides the mouse, the first adult testis-derived male stem cells spermatogonia capable of test-tube sperm production, and most recently, even haploid ES cells capable of producing Holly, a semi-cloned fertile female medaka from a mosaic oocyte created by microinjecting a haploid ES cell nucleus directly into a normal oocyte. These breakthroughs make medaka a favoring vertebrate model for stem cell research, the topic of this review. © Science China Press and Springer-Verlag Berlin Heidelberg 2010.
Source Title: Science China Life Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/53026
ISSN: 16747305
DOI: 10.1007/s11427-010-0079-3
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