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|Title:||Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer|
|Source:||Ramachandran, L.,Manu, K.A.,Shanmugam, M.K.,Li, F.,Siveen, K.S.,Vali, S.,Kapoor, S.,Abbasi, T.,Surana, R.,Smoot, D.T.,Ashktorab, H.,Tan, P.,Ahn, K.S.,Yap, C.W.,Kumar, A.P.,Sethi, G. (2012-11-02). Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. Journal of Biological Chemistry 287 (45) : 38028-38040. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M112.388702|
|Abstract:||Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential for the treatment of GC. Results: Isorhamnetin (IH) modulates PPAR-γ pathway in GC. Conclusion: IH induces apoptosis through the activation of the PPAR-γ pathway. Significance: The study proposes a novel agent for GC treatment. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.|
|Source Title:||Journal of Biological Chemistry|
|Appears in Collections:||Staff Publications|
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