Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M112.388702
Title: Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer
Authors: Ramachandran, L.
Manu, K.A. 
Shanmugam, M.K. 
Li, F.
Siveen, K.S.
Vali, S.
Kapoor, S.
Abbasi, T.
Surana, R.
Smoot, D.T.
Ashktorab, H.
Tan, P. 
Ahn, K.S.
Yap, C.W. 
Kumar, A.P. 
Sethi, G.
Issue Date: 2-Nov-2012
Source: Ramachandran, L.,Manu, K.A.,Shanmugam, M.K.,Li, F.,Siveen, K.S.,Vali, S.,Kapoor, S.,Abbasi, T.,Surana, R.,Smoot, D.T.,Ashktorab, H.,Tan, P.,Ahn, K.S.,Yap, C.W.,Kumar, A.P.,Sethi, G. (2012-11-02). Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. Journal of Biological Chemistry 287 (45) : 38028-38040. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M112.388702
Abstract: Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential for the treatment of GC. Results: Isorhamnetin (IH) modulates PPAR-γ pathway in GC. Conclusion: IH induces apoptosis through the activation of the PPAR-γ pathway. Significance: The study proposes a novel agent for GC treatment. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title: Journal of Biological Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/53005
ISSN: 00219258
DOI: 10.1074/jbc.M112.388702
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