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|Title:||Fish and chips: A microfluidic perfusion platform for monitoring zebrafish development|
Van Noort, D.
|Citation:||Choudhury, D., Van Noort, D., Iliescu, C., Zheng, B., Poon, K.-L., Korzh, S., Korzh, V., Yu, H. (2012-03-07). Fish and chips: A microfluidic perfusion platform for monitoring zebrafish development. Lab on a Chip - Miniaturisation for Chemistry and Biology 12 (5) : 892-900. ScholarBank@NUS Repository. https://doi.org/10.1039/c1lc20351g|
|Abstract:||We have developed a multi-channel microfluidic perfusion platform for culturing zebrafish embryos and capturing live images of various tissues and organs inside the embryo. The Fish and Chips was micro-fabricated in silicon and glass for reproducibility and accuracy of the microfluidic structure. The microfluidic platform consists of three parts: a microfluidic gradient generator, a row of eight fish tanks, in which the fish embryos are individually placed, and eight output channels. The fluidic gradient generator supports dose-dependent drug and chemical studies. A unique perfusion system ensures a uniform and constant flow of media to the fish tank while the wastes are efficiently removed. The fish tanks restrict the embryo movements, except rotationally, for live imaging of internal tissues and organs. The embryos showed developmental abnormalities under the influence of the drug valproic acid (VPA). © 2012 The Royal Society of Chemistry.|
|Source Title:||Lab on a Chip - Miniaturisation for Chemistry and Biology|
|Appears in Collections:||Staff Publications|
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