Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0162-0134(98)10075-2
Title: Complexes of salicylaldehyde acylhydrazones: Cytotoxicity, QSAR and crystal structure of the sterically hindered t-butyl dimer
Authors: Koh, L.L. 
Kon, O.L. 
Loh, K.W.
Long, Y.C.
Ranford, J.D. 
Tan, A.L.C.
Tjan, Y.Y.
Issue Date: Dec-1998
Citation: Koh, L.L., Kon, O.L., Loh, K.W., Long, Y.C., Ranford, J.D., Tan, A.L.C., Tjan, Y.Y. (1998-12). Complexes of salicylaldehyde acylhydrazones: Cytotoxicity, QSAR and crystal structure of the sterically hindered t-butyl dimer. Journal of Inorganic Biochemistry 72 (3-4) : 155-162. ScholarBank@NUS Repository. https://doi.org/10.1016/S0162-0134(98)10075-2
Abstract: A series of acylhydrazones of salicylaldehyde and their transition metal complexes, predominantly copper(II), have been prepared and characterized. The crystal structure of the Cu(II) complex of the sterically hindered t- butyl derivative contains a phenolato bridged dimer with the ligand coordinated as a tridentate moiety. QSAR analyses of the cytotoxicity of the chelators and their Cu(II) complexes reveals that solubility is the dominant factor for activity. Compounds display a maximum with respect to lipophilicity, allowing optimization of the bioactivity for both the ligands and their complexes. Copper complexes are significantly more cytotoxic than the metal-free ligands and complexes of other metals: Cu > Ni > Zn = Mn > Fe = Cr > Co.
Source Title: Journal of Inorganic Biochemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/52837
ISSN: 01620134
DOI: 10.1016/S0162-0134(98)10075-2
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