Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0742-8413(96)00201-0
Title: Changes in glutathione and its associated enzymes during carrageenan-induced acute inflammation in mice
Authors: Sin, Y.M. 
Pook, S.H.
Tan, T.M. 
Pettersson, A.
Kara, A.U. 
Teh, W.F.
Keywords: acute inflammation
air-pouch
carrageenan
enzymes
exudate fluid
glutathione
leucocytes
mice
Issue Date: Mar-1997
Source: Sin, Y.M., Pook, S.H., Tan, T.M., Pettersson, A., Kara, A.U., Teh, W.F. (1997-03). Changes in glutathione and its associated enzymes during carrageenan-induced acute inflammation in mice. Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology 116 (3) : 191-195. ScholarBank@NUS Repository. https://doi.org/10.1016/S0742-8413(96)00201-0
Abstract: Six-day-old air pouch of mice was used as a bioassay model for the studies of changes in the glutathione levels during carrageenan-induced acute inflammation. The exudate fluid and exudate leucocytes were both assayed for the presence of reduced glutathione (GSH) as well as oxidized glutathione (GSSG). The activities of glutathione reductase (GR) and glutathione peroxidase (GPx) were also determined. Results obtained were compared to saline-injected controls. The amount of GSH and leucocytes present in the inflammatory air pouches were significantly increased. The activity of GR but not the GPx, was also enhanced. The presence of elevated levels of GSSG implies a possible antioxidant role for GSH during inflammation.
Source Title: Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
URI: http://scholarbank.nus.edu.sg/handle/10635/52818
ISSN: 07428413
DOI: 10.1016/S0742-8413(96)00201-0
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