Please use this identifier to cite or link to this item: https://doi.org/10.1016/0021-9673(93)83007-F
Title: Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography
Authors: Ching, C.B. 
Lim, B.G. 
Lee, E.J.D.
Ng, S.C. 
Issue Date: 1993
Citation: Ching, C.B., Lim, B.G., Lee, E.J.D., Ng, S.C. (1993). Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography. Journal of Chromatography 634 (2) : 215-219. ScholarBank@NUS Repository. https://doi.org/10.1016/0021-9673(93)83007-F
Abstract: The continuous chromatographic separation of a racemic anthelmintic drug, praziquantel, was carried out using a simulated counter-current system. The system consists of four identical columns (445 mm x 12.5 mm I.D.) connected in series through solenoid valves. The chiral stationary phase used is microcrystalline cellulose triacetate and the eluent is methanol. Feed at 50 mg/ml was continuously introduced into the system at 0.3 ml/min and 429 mg/h of (+)-praziquantel and 404 mg/h of (-)-praziquantel were obtained from the extract and raffinate streams, respectively. The optical purity of the products was more than 90%. This method provides an extremely useful technique for preparative-scale enantioseparation. Compared with conventional batch preparative-scale processes, this system offers a higher solute to adsorbent mass ratio.
Source Title: Journal of Chromatography
URI: http://scholarbank.nus.edu.sg/handle/10635/52714
ISSN: 00219673
DOI: 10.1016/0021-9673(93)83007-F
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

77
checked on Nov 14, 2018

WEB OF SCIENCETM
Citations

70
checked on Oct 30, 2018

Page view(s)

62
checked on Nov 10, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.