Please use this identifier to cite or link to this item: https://doi.org/10.1163/156856201300194252
Title: Modification of gold surface by grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion
Authors: Zhang, F.
Kang, E.T. 
Neoh, K.G. 
Huang, W. 
Keywords: Gold
Graft
Platelet adhesion
Poly(ethylene glycol)
Protein adsorption
Self-assembled monolayer
Issue Date: 2001
Citation: Zhang, F., Kang, E.T., Neoh, K.G., Huang, W. (2001). Modification of gold surface by grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion. Journal of Biomaterials Science, Polymer Edition 12 (5) : 515-531. ScholarBank@NUS Repository. https://doi.org/10.1163/156856201300194252
Abstract: Gold surfaces were first treated in an alkanethiol solution to form self-assembled monolayers (SAMs). The thiolated Au surface was then subjected to Ar plasma pretreatment, followed by air exposure and UV-induced graft polymerization of poly(ethylene glycol) methacrylate (PEGMA) macromonomer. In comparison with the 3-mercaptopropionic acid-2-ethylhexyl ester (MPAEE) SAM, the (3-mercaptoproply)trimethoxysilane (MPTMS) SAM on Au exhibited higher stability under the conditions of Ar plasma pretreatment. The graft concentration of the PEGMA polymer on SAM-modified Au surface increased with increasing PEGMA macromonomer concentration and UV-graft polymerization time. The modified-Au surfaces were characterized by X-ray spectroscopy (XPS), atomic force microscopy (AFM), and water contact angle measurement. The Au surface with a high concentration of grafted PEGMA polymer could completely repel protein adsorption and platelet adhesion.
Source Title: Journal of Biomaterials Science, Polymer Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/52669
ISSN: 09205063
DOI: 10.1163/156856201300194252
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