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|Title:||Modification of gold surface by grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion|
|Citation:||Zhang, F., Kang, E.T., Neoh, K.G., Huang, W. (2001). Modification of gold surface by grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion. Journal of Biomaterials Science, Polymer Edition 12 (5) : 515-531. ScholarBank@NUS Repository. https://doi.org/10.1163/156856201300194252|
|Abstract:||Gold surfaces were first treated in an alkanethiol solution to form self-assembled monolayers (SAMs). The thiolated Au surface was then subjected to Ar plasma pretreatment, followed by air exposure and UV-induced graft polymerization of poly(ethylene glycol) methacrylate (PEGMA) macromonomer. In comparison with the 3-mercaptopropionic acid-2-ethylhexyl ester (MPAEE) SAM, the (3-mercaptoproply)trimethoxysilane (MPTMS) SAM on Au exhibited higher stability under the conditions of Ar plasma pretreatment. The graft concentration of the PEGMA polymer on SAM-modified Au surface increased with increasing PEGMA macromonomer concentration and UV-graft polymerization time. The modified-Au surfaces were characterized by X-ray spectroscopy (XPS), atomic force microscopy (AFM), and water contact angle measurement. The Au surface with a high concentration of grafted PEGMA polymer could completely repel protein adsorption and platelet adhesion.|
|Source Title:||Journal of Biomaterials Science, Polymer Edition|
|Appears in Collections:||Staff Publications|
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