Please use this identifier to cite or link to this item: https://doi.org/10.1385/ABAB:125:3:147
Title: Applications of polymer nanofibers in biomedicine and biotechnology
Authors: Venugopal, J. 
Ramakrishna, S. 
Keywords: Biotechnology
Electrospinning
Nanofibers
Scaffolds
Tissue engineering
Issue Date: Jun-2005
Source: Venugopal, J., Ramakrishna, S. (2005-06). Applications of polymer nanofibers in biomedicine and biotechnology. Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 125 (3) : 147-157. ScholarBank@NUS Repository. https://doi.org/10.1385/ABAB:125:3:147
Abstract: Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and internal molecular structures. A wide range of biodegradable biopolymers can be electrospun into mats with specific fiber arrangement and structural integrity. Through secondary processing, the nanofiber surface can be functionalized to display specific biochemical characteristics. It is hypothesized that the large surface area of nanofibers with specific surface chemistry facilitates attachment of cells and control of their cellular functions. These features of nanofiber mats are morphologically and chemically similar to the extracellular matrix of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, effective mechanical properties, and specific biochemical properties. The current emphasis of research is on exploiting such properties and focusing on determining appropriate conditions for electrospinning various polymers and biopolymers for eventual applications including multifunctional membranes, biomedical structural elements (scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, vascular grafts), protective shields in specialty fabrics, and filter media for submicron particles in the separation industry. This has resulted in the recent applications for polymer nanofibers in the field of biomedicine and biotechnology. Copyright © 2005 by Humana Press Inc. All rights of any nature whatsoever reserved.
Source Title: Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology
URI: http://scholarbank.nus.edu.sg/handle/10635/52580
ISSN: 02732289
DOI: 10.1385/ABAB:125:3:147
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

208
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

185
checked on Nov 19, 2017

Page view(s)

41
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.