Please use this identifier to cite or link to this item:
|Title:||Force-dependent cell signaling in stem cell differentiation|
|Authors:||Yim, E.K.F. |
|Citation:||Yim, E.K.F., Sheetz, M.P. (2012). Force-dependent cell signaling in stem cell differentiation. Stem Cell Research and Therapy 3 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/scrt132|
|Abstract:||Stem cells interact with biochemical and biophysical signals in their extracellular environment. The biophysical signals are transduced to the stem cells either through the underlying extracellular matrix or externally applied forces. Increasing evidence has shown that these biophysical cues such as substrate stiffness and topography can direct stem cell differentiation and determine the cell fate. The mechanism of the biophysically induced differentiation is not understood; however, several key signaling components have been demonstrated to be involved in the force-mediated differentiation. This review will focus on focal adhesions, cytoskeletal contractility, Rho GTPase signaling and nuclear regulation in connection with biophysically induced differentiation. We will briefly introduce the important components of the mechanotransduction machinery, and the recent developments in the study of force-dependent stem cell differentiation. © 2012 BioMed Central Ltd.|
|Source Title:||Stem Cell Research and Therapy|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 17, 2018
WEB OF SCIENCETM
checked on Oct 10, 2018
checked on Oct 6, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.