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Title: CellML and associated tools and techniques
Authors: Garny, A.
Nickerson, D.P. 
Cooper, J.
Santos, R.W.D.
Miller, A.K.
McKeever, S.
Nielsen, P.M.F.
Hunter, P.J.
Keywords: API
IUPS Physiome Project
Mark-up language
Modelling environment
Issue Date: 13-Sep-2008
Citation: Garny, A., Nickerson, D.P., Cooper, J., Santos, R.W.D., Miller, A.K., McKeever, S., Nielsen, P.M.F., Hunter, P.J. (2008-09-13). CellML and associated tools and techniques. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 366 (1878) : 3017-3043. ScholarBank@NUS Repository.
Abstract: We have, in the last few years, witnessed the development and availability of an ever increasing number of computer models that describe complex biological structures and processes. The multi-scale and multi-physics nature of these models makes their development particularly challenging, not only from a biological or biophysical viewpoint but also from a mathematical and computational perspective. In addition, the issue of sharing and reusing such models has proved to be particularly problematic, with the published models often lacking information that is required to accurately reproduce the published results.The International Union of Physiological Sciences Physiome Project was launched in 1997 with the aim of tackling the aforementioned issues by providing a framework for the modelling of the human body. As part of this initiative, the specifications of the CellML mark-up language were released in 2001.Now, more than 7 years later, the time has come to assess the situation, in particular with regard to the tools and techniques that are now available to the modelling community. Thus, after introducing CellML, we review and discuss existing editors, validators, online repository, code generators and simulation environments, as well as the CellML Application Program Interface. We also address possible future directions including the need for additional mark-up languages. © 2008 The Royal Society.
Source Title: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
ISSN: 1364503X
DOI: 10.1098/rsta.2008.0094
Appears in Collections:Staff Publications

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