Please use this identifier to cite or link to this item: https://doi.org/10.1038/nm.2933
Title: In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
Authors: Idris, N.M. 
Gnanasammandhan, M.K.
Zhang, J.
Ho, P.C. 
Mahendran, R. 
Zhang, Y. 
Issue Date: Oct-2012
Source: Idris, N.M.,Gnanasammandhan, M.K.,Zhang, J.,Ho, P.C.,Mahendran, R.,Zhang, Y. (2012-10). In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nature Medicine 18 (10) : 1580-1585. ScholarBank@NUS Repository. https://doi.org/10.1038/nm.2933
Abstract: Conventional photodynamic therapy (PDT) is limited by the penetration depth of visible light needed for its activation. Here we used mesoporous-silica- coated upconversion fluorescent nanoparticles (UCNs) as a nanotransducer to convert deeply penetrating near-infrared light to visible wavelengths and a carrier of photosensitizers. We also used the multicolor-emission capability of the UCNs at a single excitation wavelength for simultaneous activation of two photosensitizers for enhanced PDT. We showed a greater PDT efficacy with the dual-photosensitizer approach compared to approaches using a single photosensitizer, as determined by enhanced generation of singlet oxygen and reduced cell viability. In vivo studies also showed tumor growth inhibition in PDT-treated mice by direct injection of UCNs into melanoma tumors or intravenous injection of UCNs conjugated with a tumor-targeting agent into tumor-bearing mice. As the first demonstration, to the best of our knowledge, of the photosensitizer-loaded UCN as an in vivo-targeted PDT agent, this finding may serve as a platform for future noninvasive deep-cancer therapy. © 2012 Nature America, Inc. All rights reserved.
Source Title: Nature Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/52531
ISSN: 10788956
DOI: 10.1038/nm.2933
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