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Title: Formulation Design and Development of Transdermal Delivery System-Nanoemulsion of Schizandrol A
Authors: CHEN YE
Keywords: formulation, preformulation, cosmeceutical, transdermal delivery, colloids, nanoemulsion
Issue Date: 21-Aug-2013
Source: CHEN YE (2013-08-21). Formulation Design and Development of Transdermal Delivery System-Nanoemulsion of Schizandrol A. ScholarBank@NUS Repository.
Abstract: Schizandrol A is a lignan component that possesses multi-pharmacological benefits including anti-inflammatory, anti-cancer and anti-viral effects, whereas its practical application is hindered by low bioavailability due to poor water solubility. Oil in water nanoemulsion formulation is one of the most appealing strategies to enhance solubility and bioavailability for hydrophobic pharmaceuticals in health, personal care and food applications. This work relates to the formulation design and development of sucrose laurate-based nanoemulsion containing schizandrol A for transdermal delivery with an aim to resolve the limitations. Nanoemulsion components were selected based on their capacity to solubilize schizandrol A. High pressure homogenization method was used to fabricate nanoemulsion with low surfactant concentration. Effects of composition and process variables on droplet size and polydispersity index were investigated. In vitro permeation test and stability studies were performed. Optimized nanoemulsions containing schizandrol A were developed without destabilization phenomena over storage and on temperature.
Appears in Collections:Ph.D Theses (Open)

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