Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/51998
Title: Formulation Design and Development of Transdermal Delivery System-Nanoemulsion of Schizandrol A
Authors: CHEN YE
Keywords: formulation, preformulation, cosmeceutical, transdermal delivery, colloids, nanoemulsion
Issue Date: 21-Aug-2013
Source: CHEN YE (2013-08-21). Formulation Design and Development of Transdermal Delivery System-Nanoemulsion of Schizandrol A. ScholarBank@NUS Repository.
Abstract: Schizandrol A is a lignan component that possesses multi-pharmacological benefits including anti-inflammatory, anti-cancer and anti-viral effects, whereas its practical application is hindered by low bioavailability due to poor water solubility. Oil in water nanoemulsion formulation is one of the most appealing strategies to enhance solubility and bioavailability for hydrophobic pharmaceuticals in health, personal care and food applications. This work relates to the formulation design and development of sucrose laurate-based nanoemulsion containing schizandrol A for transdermal delivery with an aim to resolve the limitations. Nanoemulsion components were selected based on their capacity to solubilize schizandrol A. High pressure homogenization method was used to fabricate nanoemulsion with low surfactant concentration. Effects of composition and process variables on droplet size and polydispersity index were investigated. In vitro permeation test and stability studies were performed. Optimized nanoemulsions containing schizandrol A were developed without destabilization phenomena over storage and on temperature.
URI: http://scholarbank.nus.edu.sg/handle/10635/51998
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
PhD thesis_CHEN Ye 2013.pdf9.68 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

172
checked on Dec 11, 2017

Download(s)

1,160
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.