Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/51996
Title: Lipids and cognition in Chinese older adults: Investigating APOE, PON1, N-3 PUFA in the Singapore Longitudinal Aging studies
Authors: GAO QI
Keywords: cognition,elderly, APOE, PON1, n-3 PUFA, dementia
Issue Date: 11-Dec-2013
Source: GAO QI (2013-12-11). Lipids and cognition in Chinese older adults: Investigating APOE, PON1, N-3 PUFA in the Singapore Longitudinal Aging studies. ScholarBank@NUS Repository.
Abstract: Some lipids could function as cognitive protective/risk factors; however, published findings are inconsistent and insufficient. We conducted cross-sectional, longitudinal and case-control studies to examine the relationship of APOE e4, PON1 gene polymorphism, n-3 PUFA and cognition in elderly Chinese Singaporeans who were recruited from two sources: (1) patients with confirmed dementia diagnosis from Alexandra Hospital and (2) participants in the Singapore Longitudinal Ageing Study (SLAS) with a median of 1.5years follow-up. The results showed that daily n-3 PUFA supplements consumption was independently associated with less cognitive decline and better cognitive performance in the elderly. PON1 gene R allele carriers in the mixed dementia group presented with more neuropsychiatric symptoms and greater severity of dementia. APOE e4 was associated with increased risk of AD. The PON1 R allele was associated with increased risk of non-AD dementia and was more frequent among non-AD dementia patients who were APOE e4 non-carriers.
URI: http://scholarbank.nus.edu.sg/handle/10635/51996
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