Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/51991
Title: Gene expression profile in the middle cerebral artery and frontal cortex of Hypertensive rabbits
Authors: JIN SHALAI
Keywords: stroke, hypertension, 2-kidney 1-clip, microarray analysis, frontal cortex, middle cerebral artery
Issue Date: 16-Jul-2012
Source: JIN SHALAI (2012-07-16). Gene expression profile in the middle cerebral artery and frontal cortex of Hypertensive rabbits. ScholarBank@NUS Repository.
Abstract: This study presents an expression profile of various genes that are involved and regulated in hypertension in both intra- and extracranial vessels. The expression of genes and extension of damage to cerebral arteries caused by hypertension were evaluated quantitatively and morphologically in 10 New Zealand White rabbits with and without hypertension, induced using the 2-kidney, 1-clip Goldblatt hypertension model. Genes in the frontal cortex and middle cerebral artery respectively were filtered from microarray analysis and subjected to the Ingenuity Pathway Analysis. From the selection of our genes of interest, 8 genes PPARA, PRL-R, PTGDR, P450, Gab3, Tnfs14, Sell and Lass3 were verified by RT-PCR. These genes have shown to be involved in the progression or contribution towards inflammatory diseases such as atherosclerosis thus further study of these genes may lead to a better understanding on the role of hypertension in stroke.
URI: http://scholarbank.nus.edu.sg/handle/10635/51991
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