Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/51974
Title: Role of Hydrogen Sulfide in the Cardiovascular system: Implications for treatment of Cardiovascular Diseases
Authors: LIU YI TONG
Keywords: hydrogen sulfide, cardiovascular, hypertension, heart failure, cardiac mast cell, renin
Issue Date: 13-Nov-2013
Source: LIU YI TONG (2013-11-13). Role of Hydrogen Sulfide in the Cardiovascular system: Implications for treatment of Cardiovascular Diseases. ScholarBank@NUS Repository.
Abstract: Renin is the rate-limiting enzyme involved in renin-angiotensin system. Renin elevation occurs during pathological states of renal ischemia (renin in systematic circulation) or cardiac remodeling (renin in local tissue). Our present study clearly demonstrated the ability of H2S to suppress renin elevation by preventing renin release from renin-rich kidney granular cells or cardiac mast cells, both by attenuating cAMP increment, thus limiting the detrimental effects of renin in renal hypertension or heart failure, respectively. Our results shed new lights to the underlying mechanisms of H2S-induced protection, and support H2S as a promising therapeutic treatment against renin-dependent pathological diseases.
URI: http://scholarbank.nus.edu.sg/handle/10635/51974
Appears in Collections:Master's Theses (Open)

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