Please use this identifier to cite or link to this item:
|Title:||Study of the Characterization and Crystallization of 4-Hydroxy-2-Pyrrolidone|
|Authors:||Wang, X.J. |
|Citation:||Wang, X.J., Wiehler, H., Ching, C.B. (2004). Study of the Characterization and Crystallization of 4-Hydroxy-2-Pyrrolidone. Chirality 16 (4) : 220-227. ScholarBank@NUS Repository. https://doi.org/10.1002/chir.20021|
|Abstract:||A systematic study of the characterization for racemic species of 4-hydroxy-2-pyrrolidone was undertaken. The melting point phase diagram of (R)- and (S)-4-hydroxy-2-pyrrolidone was determined by differential scanning calorimetry. The ternary phase diagram of (R)- and (S)-4-hydroxy-2-pyrrolidone with isopropanol was constructed at 15, 20, 25, and 35°C. The crystalline nature of 4-hydroxy-2-pyrrolidone racemate was also characterized by means of comparison of solid-state FTIR spectra and powder X-ray diffraction patterns of the racemic mixture with those of one of the enantiomers. It is shown that (±)-4-hydroxy-2-pyrrolidone is a racemic conglomerate. The enthalpies of fusion of (R)-4-hydroxy-2-pyrrolidone and (±)-4-hydroxy-2-pyrrolidone and entropy of mixing of (R)- and (S)-4-hydroxy-2-pyrrolidone were calculated using the thermodynamic data. The solubility and supersolubility diagrams of (R)- and (S)-4-hydroxy-2-pyrrolidone in isopropanol were determined over a temperature range of 4-35°C. The optical resolution of (± )-4-hydroxy-2-pyrrolidone was successfully achieved by preferential crystallization. © 2004 Wiley-Liss, Inc.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 23, 2019
WEB OF SCIENCETM
checked on Jan 7, 2019
checked on Dec 22, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.