Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bej.2004.05.007
Title: Optimal design and operation of SMB bioreactor: Production of high fructose syrup by isomerization of glucose
Authors: Zhang, Y.
Hidajat, K. 
Ray, A.K. 
Keywords: Bioprocess design
Chromatography
Design
Dynamic simulation
Enzyme bioreactors
Food processing
Fructose
Genetic algorithm
Integrated processing
Jumping genes
Moving bed bioreactors
Optimization
Issue Date: Oct-2004
Source: Zhang, Y.,Hidajat, K.,Ray, A.K. (2004-10). Optimal design and operation of SMB bioreactor: Production of high fructose syrup by isomerization of glucose. Biochemical Engineering Journal 21 (2) : 111-121. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bej.2004.05.007
Abstract: The isomerization of glucose to fructose is an important industrial process in obtaining high fructose syrup, a sweetener widely used in food industry. In this work, a hybrid simulated moving bed reactor (SMBR) system is optimized using experimentally verified dynamic SMB model to maximize the net productivity of HFS55 using minimum solvent. An adaptation of the state-of-the-art AI-based robust optimization technique, non-dominated sorting genetic algorithm with jumping genes (NSGA-II-JG) is used in finding the Pareto (non-dominated) solutions for both the existing as well as SMBR system at the design stage. Finally, SMBR configuration was modified to further improve the system performance. Systematic multi-objective optimization resulted in significant performance improvement. Moreover, the new optimization technique gives much faster, smoother and larger spread of the Pareto-optimal solutions. © 2004 Elsevier B.V. All rights reserved.
Source Title: Biochemical Engineering Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/51797
ISSN: 1369703X
DOI: 10.1016/j.bej.2004.05.007
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