Please use this identifier to cite or link to this item: https://doi.org/10.1557/opl.2012.545
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dc.titlePractical considerations for medical applications using biological grafts and their derivatives
dc.contributor.authorMukherjee, S.
dc.contributor.authorReddy, V.J.
dc.contributor.authorRavichandran, R.
dc.contributor.authorMathapati, S.
dc.contributor.authorGuhathakurta, S.
dc.contributor.authorRaghunath, M.
dc.contributor.authorRamakrishna, S.
dc.date.accessioned2014-04-24T10:17:35Z
dc.date.available2014-04-24T10:17:35Z
dc.date.issued2012
dc.identifier.citationMukherjee, S.,Reddy, V.J.,Ravichandran, R.,Mathapati, S.,Guhathakurta, S.,Raghunath, M.,Ramakrishna, S. (2012). Practical considerations for medical applications using biological grafts and their derivatives. Materials Research Society Symposium Proceedings 1418 : 215-240. ScholarBank@NUS Repository. <a href="https://doi.org/10.1557/opl.2012.545" target="_blank">https://doi.org/10.1557/opl.2012.545</a>
dc.identifier.isbn9781605113951
dc.identifier.issn02729172
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/51642
dc.description.abstractThe art and science of using biological tissue grafts from animal and human sources for various ailments is nascent. Various research groups around the world are actively investigating the potential prostheses of biological origin. Biological tissue grafts are rendered acellular through various methods of processing and fabrication before they are used for the specific purpose. The remainder is a scaffold that offers framework for host cellular repopulation and revascularization. Different methods of fixation have been explored over several decades to render the biological grafts suitable for use with or without extraction of cells. Therefore, methods such as glutaraldehyde and polyepoxide crosslinking treatments and dye-mediated photooxidation have been developed to stabilize and deantigenize the tissue while attempting to maintain its natural mechanical properties. Also, residual cellular components in a bioprosthetic material have been associated with undesired effects, such as calcification and immunological recognition, and thus have been the motivation for various decellularization processes. The effects of these stabilization and decellularization treatments on mechanical, biological and chemical properties of treated tissues have been investigated, specifically with regard to calcification, immunogenicity, and cytotoxicity concerns. Naturally derived biological scaffolds offer many mechanical, chemical and biological advantages over synthetic materials, and thus hold tremendous potential for use in tissue engineering therapies. Therefore the rationale of using biological grafts in usable forms is gaining importance in order to avoid unwanted chronic inflammatory reactions. This review article discusses the need for such bioprosthetics and the potential role for natural tissues in various applications. © 2012 Materials Research Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1557/opl.2012.545
dc.sourceScopus
dc.subjectBiological graft
dc.subjectBiomaterials
dc.subjectDecellularized tissue
dc.subjectECM
dc.subjectTissue engineering
dc.typeConference Paper
dc.contributor.departmentNUS NANOSCIENCE & NANOTECH INITIATIVE
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1557/opl.2012.545
dc.description.sourcetitleMaterials Research Society Symposium Proceedings
dc.description.volume1418
dc.description.page215-240
dc.description.codenMRSPD
dc.identifier.isiutNOT_IN_WOS
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