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|Title:||Relationships between the folding rate constant and the topological parameters of small two-state proteins based on general random walk model|
Random walk model
|Citation:||Mi, D., Liu, G.R., Wang, J.-S., Li, Z.R. (2006-07-07). Relationships between the folding rate constant and the topological parameters of small two-state proteins based on general random walk model. Journal of Theoretical Biology 241 (1) : 152-157. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jtbi.2005.11.011|
|Abstract:||In this paper, we propose an analytically tractable model of protein folding based on one-dimensional general random walk. A second-order differential equation for the mean folding time of a single protein is constructed which can be used to derive the observed relationship between the folding rate constant and the number of native contacts. The parameters appearing in the model can be determined by fitting the theoretical prediction to the experimental result. In addition, taking into account the fact that the number of native contacts is almost proportional to the relative contact order, we can also explain the observed relationship between the folding rate constant and the relative contact order. © 2005 Elsevier Ltd. All rights reserved.|
|Source Title:||Journal of Theoretical Biology|
|Appears in Collections:||Staff Publications|
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