Please use this identifier to cite or link to this item: https://doi.org/10.1002/elps.200800257
Title: Realistic simulations of combined DNA electrophoretic flow and EOF in nano-fluidic devices
Authors: Duong-Hong, D.
Han, J.
Wang, J.-S. 
Hadjiconstantinou, N.G.
Chen, Y.Z. 
Liu, G.-R. 
Keywords: Debye layer
Dissipative particle dynamics method
DNA separation
Entropic trapping
Microfluidics
Issue Date: 2008
Source: Duong-Hong, D., Han, J., Wang, J.-S., Hadjiconstantinou, N.G., Chen, Y.Z., Liu, G.-R. (2008). Realistic simulations of combined DNA electrophoretic flow and EOF in nano-fluidic devices. Electrophoresis 29 (24) : 4880-4886. ScholarBank@NUS Repository. https://doi.org/10.1002/elps.200800257
Abstract: We present a three-dimensional dissipative particle dynamics model of DNA electrophoretic flow that captures both DNA stochastic motion and hydrodynamics without requiring expensive molecular dynamics calculations. This model enables us to efficiently and simultaneously simulate DNA electrophoretic flow and local EOF (generated by counterions near the DNA backbone), in mesoscale (~μm) fluidic devices. Our model is used to study the electrophoretic separation of long DNA chains under entropic trapping conditions [Han and Craighead, Science 2000, 288, 1026-1029]. Our simulation results are in good agreement with experimental data for realistic geometries (tapered walls) and reveal that wall tapering in entropic traps has a profound impact in the DNA trapping behavior, an effect which was largely ignored in previous modeling. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Electrophoresis
URI: http://scholarbank.nus.edu.sg/handle/10635/51511
ISSN: 01730835
DOI: 10.1002/elps.200800257
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

17
checked on Nov 14, 2017

Page view(s)

43
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.