Please use this identifier to cite or link to this item: https://doi.org/10.1002/app.20652
Title: Numerical simulation of controlled nifedipine release from chitosan microgels
Authors: Li, H. 
Yan, G.
Wu, S.
Wang, Z.
Lam, K.Y. 
Keywords: Drug delivery systems
Kinetics
Microgels
Modeling
Simulation
Issue Date: 15-Aug-2004
Source: Li, H., Yan, G., Wu, S., Wang, Z., Lam, K.Y. (2004-08-15). Numerical simulation of controlled nifedipine release from chitosan microgels. Journal of Applied Polymer Science 93 (4) : 1928-1937. ScholarBank@NUS Repository. https://doi.org/10.1002/app.20652
Abstract: The numerical simulating investigation of drug delivery can provide deeper insight into drug release mechanisms and elucidate efficiently the influences of various physical parameters. Controlled nifedipine release from nonswellable chitosan sphere-based microgels is investigated numerically with a mathematical model in this article. The mathematical model takes into account both drug dissolution and drug diffusion through the continuous matrices of the spherical microgels. Meshless Hermite-cloud method is employed to solve the formulated partial differ-ential equations. It is seen that the model well describes the nifedipine release process from the spherical chitosan microgels. The effect of several important physical parameters on drug release is evaluated, which include microsphere radius, equivalent drug saturation concentration, drug diffusion coefficient, and drug dissolution rate constant. © 2004 Wiley Periodicals, Inc.
Source Title: Journal of Applied Polymer Science
URI: http://scholarbank.nus.edu.sg/handle/10635/51485
ISSN: 00218995
DOI: 10.1002/app.20652
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