Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2003.08.042
Title: Electrospun P(LLA-CL) nanofiber: A biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation
Authors: Mo, X.M. 
Xu, C.Y. 
Kotaki, M. 
Ramakrishna, S. 
Keywords: Electrospinning
Endothelial cell
Nanofiber
Poly(L-lactide-co-ε-caprolactone)
Scaffold
Smooth muscle cell
Issue Date: May-2004
Source: Mo, X.M., Xu, C.Y., Kotaki, M., Ramakrishna, S. (2004-05). Electrospun P(LLA-CL) nanofiber: A biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation. Biomaterials 25 (10) : 1883-1890. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2003.08.042
Abstract: Poly(L-lactide-co-ε-caprolactone) [P(LLA-CL)] with L-lactide to ε-caprolactone ratio of 75 to 25 has been electrospun into nanofibers. The relationship between electrospinning parameters and fiber diameter has been investigated. The fiber diameter decreased with decreasing polymer concentration and with increasing electrospinning voltage. The X-ray diffractometer and differential scanning colorimeter results suggested that the electrospun nanofibers developed highly oriented structure in CL-unit sequences during the electrospinning process. The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds. © 2003 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/51399
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2003.08.042
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