Please use this identifier to cite or link to this item: https://doi.org/10.1098/rsif.2010.0018.focus
Title: Computational model of cell positioning: Directed and collective migration in the intestinal crypt epithelium
Authors: Wong, S.Y. 
Chiam, K.-H.
Lim, C.T. 
Matsudaira, P. 
Keywords: Cell translocation
Cellular potts model
Differential adhesion
EphB/ephrinB
Epithelial cell positioning
Issue Date: 6-Jun-2010
Source: Wong, S.Y., Chiam, K.-H., Lim, C.T., Matsudaira, P. (2010-06-06). Computational model of cell positioning: Directed and collective migration in the intestinal crypt epithelium. Journal of the Royal Society Interface 7 (SUPPL. 3) : S351-S363. ScholarBank@NUS Repository. https://doi.org/10.1098/rsif.2010.0018.focus
Abstract: The epithelium of the intestinal crypt is a dynamic tissue undergoing constant regeneration through cell growth, cell division, cell differentiation and apoptosis. How the epithelial cells maintain correct positioning and how they migrate in a directed and collective fashion are still not well understood. In this paper, we developed a computational model to elucidate these processes. We show that differential adhesion between epithelial cells, caused by the differential activation of EphB receptors and ephrinB ligands along the crypt axis, is necessary to regulate cell positioning. Differential cell adhesion has been proposed previously to guide cell movement and cause cell sorting in biological tissues. The proliferative cells and the differentiated post-mitotic cells do not intermingle as long as differential adhesion is maintained. We also show that, without differential adhesion, Paneth cells are randomly distributed throughout the intestinal crypt. In addition, our model suggests that, with differential adhesion, cells migrate more rapidly as they approach the top of the intestinal crypt. Finally, by calculating the spatial correlation function of the cell velocities, we observe that differential adhesion results in the differentiated epithelial cells moving in a coordinated manner, where correlated velocities are maintained at large distances, suggesting that differential adhesion regulates coordinated migration of cells in tissues. © 2010 The Royal Society.
Source Title: Journal of the Royal Society Interface
URI: http://scholarbank.nus.edu.sg/handle/10635/51358
ISSN: 17425689
DOI: 10.1098/rsif.2010.0018.focus
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

29
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

28
checked on Nov 13, 2017

Page view(s)

46
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.