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Title: Cell adhesion properties on-photochemically functionalized diamond
Authors: Chong, K.F.
Loh, K.P. 
Vedula, S.R.K. 
Lim, C.T. 
Sternschulte, H.
Steinmüller, D.
Sheu, F.-S. 
Zhong, Y.L.
Issue Date: 8-May-2007
Source: Chong, K.F., Loh, K.P., Vedula, S.R.K., Lim, C.T., Sternschulte, H., Steinmüller, D., Sheu, F.-S., Zhong, Y.L. (2007-05-08). Cell adhesion properties on-photochemically functionalized diamond. Langmuir 23 (10) : 5615-5621. ScholarBank@NUS Repository.
Abstract: The biocompatibility of diamond was investigated with a view toward correlating surface chemistry and topography with cellular adhesion and growth. The adhesion properties of normal human dermal fibroblast (NHDF) cells on microcrystalline and ultrananocrystalline diamond (UNCD) surfaces were measured using atomic force microscopy. Cell adhesion forces increased by several times on the hydrogenated diamond surfaces after UV irradiation of the surfaces in air or after functionalization with undecylenic acid. A direct correlation between initial cell adhesion forces and the subsequent cell growth was observed. Cell adhesion forces were observed to be strongest on UV-treated UNCD, and cell growth experiments showed that UNCD was intrinsically more biocompatible than microcrystalline diamond surfaces. The surface carboxylic acid groups on the functionalized diamond surface provide tethering sites for laminin to support the growth of neuron cells. Finally, using capillary injection, a surface gradient of polyethylene glycol could be assembled on top of the diamond surface for the construction of a cell gradient. © 2007 American Chemical Society.
Source Title: Langmuir
ISSN: 07437463
DOI: 10.1021/la070037y
Appears in Collections:Staff Publications

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