Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/50285
Title: CHARACTERISATION OF THE ANTI-VIRAL T-CELL RESPONSE INDUCED BY HUMAN CD137 LIGAND DENDRITIC CELLS
Authors: ZULKARNAIN HARFUDDIN
Keywords: CD137, CD137 ligand, dendritic cell, immunotherapy, T-cell responses
Issue Date: 30-Dec-2013
Source: ZULKARNAIN HARFUDDIN (2013-12-30). CHARACTERISATION OF THE ANTI-VIRAL T-CELL RESPONSE INDUCED BY HUMAN CD137 LIGAND DENDRITIC CELLS. ScholarBank@NUS Repository.
Abstract: Dendritic cell (DC) vaccine is a potent form of therapy useful for the treatment of cancer. DCs are professional antigen-presenting cells that are essential in orchestrating T-cell mediated immunity and this property has prompted intense research in the use of DC-based immunotherapy. Here, we describe a potent and novel type of DCs (CD137L-DCs) which are generated by CD137 ligand (CD137L) reverse signalling into peripheral monocytes with the capacity to induce superior antigen-specific T-cell response. Using cytomegalovirus pp65 peptides, we show that CD137L-DCs are able to potently activate both CD8+ and CD4+ pp65-specific T cells to a level superior than those activated by classical DCs. More importantly, these CD137L-DC-activated T cells are able to induce a stronger antigen-specific killing of HLA-matched target cells than classical DC-activated T cells. In essence, the data shows that CD137L-DCs are unique DCs with potent T-cell activating capacity and should be evaluated for human immunotherapy.
URI: http://scholarbank.nus.edu.sg/handle/10635/50285
Appears in Collections:Ph.D Theses (Open)

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