Please use this identifier to cite or link to this item: https://doi.org/10.1017/S1041610212001068
Title: The Montreal Cognitive Assessment is superior to the MiniMental State Examination in detecting patients at higher risk of dementia
Authors: Dong, Y. 
Lee, W.Y. 
Basri, N.A.
Collinson, S.L. 
Merchant, R.A. 
Venketasubramanian, N. 
Chen, C.L.-H. 
Keywords: memory clinics
mild cognitive impairment
screening
Issue Date: Nov-2012
Source: Dong, Y., Lee, W.Y., Basri, N.A., Collinson, S.L., Merchant, R.A., Venketasubramanian, N., Chen, C.L.-H. (2012-11). The Montreal Cognitive Assessment is superior to the MiniMental State Examination in detecting patients at higher risk of dementia. International Psychogeriatrics 24 (11) : 1749-1755. ScholarBank@NUS Repository. https://doi.org/10.1017/S1041610212001068
Abstract: Background: To examine the discriminant validity of the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) in detecting patients with cognitive impairment at higher risk for dementia at a memory clinic setting. Methods: Memory clinic patients were administered the MoCA, MMSE, and a comprehensive formal neuropsychological battery. Mild cognitive impairment (MCI) subtypes were dichotomized into two groups: single domainMCI (sdMCI) and multiple domain-MCI (mdMCI). Area under the receiver operating characteristic curve (ROC) analysis was used to compare the discriminatory ability of the MoCA and the MMSE. Results: Two hundred thirty patients were recruited, of which 136 (59.1%) were diagnosed with dementia, 61 (26.5%) with MCI, and 33 (14.3%) with no cognitive impairment (NCI). The majority of MCI patients had mdMCI (n=36, 59%). The MoCA had significantly larger AUCs than the MMSE in discriminating mdMCI from the lower risk group for incident dementia (NCI and sdMCI) [MoCA 0.92 (95% CI, 0.86 0.98) vs. MMSE 0.84 (95% CI, 0.750.92), p=0.02). At their optimal cut-off points, the MoCA (19/20) remained superior to the MMSE (23/24) in detecting mdMCI [sensitivity: 0.83 vs. 0.72; specificity: 0.86 vs. 0.83; PPV: 0.79 vs. 0.72; NPV: 0.89 vs. 0.83; correctly classified: 85.1% vs. 78.7%]. Conclusion: The MoCA is superior to the MMSE in the detection of patients with cognitive impairment at higher risk for incident dementia at a memory clinic setting. © International Psychogeriatric Association 2012.
Source Title: International Psychogeriatrics
URI: http://scholarbank.nus.edu.sg/handle/10635/49979
ISSN: 10416102
DOI: 10.1017/S1041610212001068
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